发明名称 |
Method for the detection of chromosomal aneuploidies |
摘要 |
The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation of allele ratio indicates the presence of chromosomal aneuploidy. |
申请公布号 |
US7645576(B2) |
申请公布日期 |
2010.01.12 |
申请号 |
US20060384128 |
申请日期 |
2006.03.17 |
申请人 |
THE CHINESE UNIVERSITY OF HONG KONG |
发明人 |
LO YUK-MING DENNIS;CHIU ROSSA WAI KWUN;TSUI BO YIN;DING CHUNMING;CANTOR CHARLES |
分类号 |
C07H21/04;C12Q1/68 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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