发明名称 |
NOVEL VACCINES AGAINST MULTIPLE SUBTYPES OF INFLUENZA VIRUS |
摘要 |
An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing an influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-proteip (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e -NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided. |
申请公布号 |
WO2009073330(A3) |
申请公布日期 |
2010.01.07 |
申请号 |
WO2008US83281 |
申请日期 |
2008.11.12 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;VGX PHARMACEUTICALS, INC;DRAGHIA-AKLI, RUXANDRA;WEINER, DAVID, B.;YAN, JIAN;LADDY, DOMINICK |
发明人 |
DRAGHIA-AKLI, RUXANDRA;WEINER, DAVID, B.;YAN, JIAN;LADDY, DOMINICK |
分类号 |
A01N43/04;A61K31/70 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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