RATIONALLY-DESIGNED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN DNASE HYPERSENSITIVE REGIONS OF THE HUMAN GENOME
摘要
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
申请公布号
WO2009076292(A3)
申请公布日期
2010.01.07
申请号
WO2008US85878
申请日期
2008.12.08
申请人
PRECISION BIOSCIENCES, INC.;JANTZ, DEREK;NICHOLSON, MICHAEL, G.;SMITH, JAMES, JEFFERSON
发明人
JANTZ, DEREK;NICHOLSON, MICHAEL, G.;SMITH, JAMES, JEFFERSON