发明名称 |
CONTROLLED AND LOCALIZED RELEASE OF RETINOIDS TO IMPROVE NEOINTIMAL HYPERPLASIA |
摘要 |
Controlled release vascular implants, such as vascular grafts, stents, wraps, and gels comprising a biocompatible polymer and all trans retinoic acid (ATRA), or its derivatives, can be used to treat, prevent, or inhibit thrombosis and/or neointimal hyperplasia which may otherwise be induced by prosthetic implantation. In particular, the implants herein can inhibit smooth muscle cell proliferation, neointimal hyperplasia, and upregulate antithrombotic genes and nitric oxide production in the vasculature. Further, the implants are capable of delivering controlled and predictable localized concentrations of ATRA. |
申请公布号 |
WO2010003076(A2) |
申请公布日期 |
2010.01.07 |
申请号 |
WO2009US49546 |
申请日期 |
2009.07.02 |
申请人 |
VESSELTEK BIOMEDICAL, LLC;AMEER, GUILLERMO, A.;KIBBE, MELINA;WEBB, ANTONIO |
发明人 |
AMEER, GUILLERMO, A.;KIBBE, MELINA;WEBB, ANTONIO |
分类号 |
A61L31/04;A61L31/10;A61L31/16 |
主分类号 |
A61L31/04 |
代理机构 |
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代理人 |
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地址 |
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