THERAPEUTIC MONOCLONAL ANTIBODIES THAT NEUTRALIZE BOTULINUM NEUROTOXINS
摘要
This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
申请公布号
WO2009008916(A3)
申请公布日期
2010.01.07
申请号
WO2008US03767
申请日期
2008.03.21
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNINA;MARKS, JAMES D.;GEREN, ISIN, N.;GARCIA, MARIA CONSUELO;LOU, JIANLONG;RAZAI, ALI
发明人
MARKS, JAMES D.;GEREN, ISIN, N.;GARCIA, MARIA CONSUELO;LOU, JIANLONG;RAZAI, ALI