| 摘要 |
1,202,770. Derivatives of 2 - formyl - quinoxaline - di - N - oxides. CHAS. PFIZER & CO. Inc. 18 Oct., 1968 [5 July, 1968], No. 49673/68. Heading C2C. Derivatives of 2 - formyl - quinoxaline - di - N oxide of the formula wherein X is H, Br, Cl, F, CF 3 , NH 2 , OH, SH, C 1-4 alkyl, C 1-4 alkoxy, or C 1-4 alkylsulphonyl and R is -NHCONH 2 , -NHCSNH 2 , NHC (: NH)NH 2 , -NHR<SP>2</SP>, -NHCOOR<SP>3</SP>, -NHCOR<SP>4</SP>, OR<SP>5</SP>, 3 - (2 - oxazolidonyl or 1 - [4 - (# - hydroxyethyl)piperazine], wherein R<SP>2</SP> is phenyl, benzyl, C 1-4 alkyl, C 1-4 hydroxyalkyl, R<SP>3</SP> is C 1-6 alkyl, C 1-6 , hydroxyalkyl or C 1-6 haloalkyl, R<SP>4</SP> is C 1-4 alkyl or phenyl, and R<SP>5</SP> is H or C 1-4 alkyl are prepared by reacting an acetalquinoxaline - di - N - oxide of the formula wherein R<SP>1</SP> is C 1-4 alkyl and wherein one R<SP>1</SP> may be bonded to the other R<SP>1</SP> and Y is -COOR<SP>1</SP> with at least an equimolar amount of RNH 2 in an inert solvent at a temperature of 30‹ to 200‹ C. for a period of up to about 24 hours in the presence of at least a catalytic amount of a strong acid. Reference has been directed by the Comptroller to Specification 1,058,047. |
