摘要 |
Provided herein are sirtuin-modulating compounds of formula (II) The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. |
申请人 |
SIRTRIS PHARMACEUTICALS, INC.;VU, CHI, B.;DISCH, JEREMY, S.;NG, PUI, YEE;BLUM, CHARLES, A.;PERNI, ROBERT, B. |
发明人 |
VU, CHI, B.;DISCH, JEREMY, S.;NG, PUI, YEE;BLUM, CHARLES, A.;PERNI, ROBERT, B. |