METHOD TO INDUCE AND EXPAND THERAPEUTIC ALLOANTIGEN- SPECIFIC HUMAN REGULATORY T CELLS IN LARGE-SCALE

摘要

Methods for inducing, expanding, and/or generating alloantigen-specif?c regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4+CD25" T cells by using CD40- activated B cells. The regulatory T cells can be human T cells. In one embodiment, the alloantigen-specific human regulatory T cells can be CD4hIghCD25±Foxp3+ regulatory T cells.