ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF

摘要

Inhibitors of the oncogenic tyrosine kinase ALK and of the Bcr-Abl mutant T315I Bcr-Abl, such as a compound of formula (I) wherein Q, T, W, K, J, Y, X, Z are independently selected from C, N, S, O, provided that the corresponding rings are (hetero)aromatic; n=0 or 1; q=1 or 2; pharmaceutical compositions containing the same and their use for the treatment of hyper-proliferative diseases.