PHARMACEUTICAL COMPOSITION CONTAINING SURFACE-COATED MICROPARTICLES

摘要

Disclosed is a pharmaceutical composition which can be used for the administration of a low-molecular-weight substance or a high-molecular-weight substance such as a peptide and a protein by a means other than injection with high efficiency.  Also disclosed is a method for producing the composition. Specifically disclosed is a pharmaceutical composition for transmucosal administration, which comprises (a) a substance which can carry a positive or negative electrical charge at a given pH value, (b) pharmaceutically acceptable microparticles, and (c) a pharmaceutically acceptable surface-coating polymer which can be electrically charged at the above-mentioned pH value.  In the composition, the surface-coating polymer coats the surfaces of the microparticles, and the substance is immobilized on the surfaces of the microparticles through the surface-coating polymer.  In the composition, the microparticles interact non-covalently with the surface-coating polymer and, at the same time, the surface-coating polymer interacts electrostatically with the substance, thereby forming a complex.