摘要 |
<p>This disclosure provides a multi-target fusion protein composed of a TGF? antagonist domain and another binding domain antagonistic for a heterologous target (such as IL6, IL10, VEGF, TNF, HGF, TWEAK, IGF) or agonistic for a heterologous target (such as GITR). The multi-specific fusion protein may also include an intervening domain that separates the binding domains and allows for dimerization. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.</p> |
申请人 |
TRUBION PHARMACEUTICALS, INC.;LOFQUIST, ALAN, KEITH;BAUM, PETER, ROBERT;THOMPSON, PETER, ARMSTRONG;MISHER, LYNDA |
发明人 |
LOFQUIST, ALAN, KEITH;BAUM, PETER, ROBERT;THOMPSON, PETER, ARMSTRONG;MISHER, LYNDA |