METHOD FOR PRODUCTION OF RECOMBINANT PROTEIN BY USING GENETICALLY ENGINEERED BREVIBACILLUS BACTERIUM

摘要

In the production of a recombinant protein by using a genetically engineered Brevibacillus bacterium, the culture of the bacterium is carried out by using fructose as a carbon source.  This is a novel condition for culturing the Brevibacillus bacterium, which enables the improvement in the quantity of the recombinant protein secreted/produced per cell and the increase in the density of cells during the culture and also enables the preparation of the recombinant protein at a lower cost compared with those achieved by conventional techniques, and can be scaled up to an industrial level.