PIPERAZINE DITHIOCTATE AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME

摘要

PURPOSE: A pharmaceutical composition containing piperazine dithioctate is provided to ensure high solubility and stability to heat and moisture and prevent or treat multiple neuritis. CONSTITUTION: A piperazine dithioctate which is a novel basic additive salt of thioctic acid is denoted by chemical formula I. The thioctic acid is racemic form. The thioctic acid is R-(+)-thioctic acid or S-(-)-thioctic acid. The diffraction angle value of crystalline piperazine dithioctate is 13.9±0.2, 16.3±0.2, 17.1±0.2, 17.3±0.2, 18.2±0.2, 18.9±0.2, 20.5±0.2, 22.2±0.2, 22.8±0.2, 24.2±0.2, and 39.3±0.2. A pharmaceutical composition contains the piperazine dithioctate and pharmaceutically acceptable carrier. The pharmaceutical composition is used for treating or preventing multiple neuritis, dementia, Alzheimer, rheumatoid arthritis or suppressing increase of lipid in blood vessel.