MICRONEEDLE DEVICE, AND METHOD FOR ENHANCING THE EFFICACY OF INFLUENZA VACCINE BY USING MICRONEEDLE DEVIVE

摘要

Disclosed is an immunogenicity enhancement method by using a microneedle device, which can enhance the immunogenicity of an influenza vaccine. In the immunogenicity enhancement method by using a microneedle device, a microneedle device comprising microneedles composed of a poly (lactic acid) coated with an influenza vaccine is put on the skin so as to administer the influenza vaccine transdermally, wherein the influenza vaccine comprises an antigen comprising a type-A strain (H1N1), a type-A strain (H3N2) and a type-B strain as active ingredients.  After the transdermal administration, lauryl alcohol is applied to a part on the skin on which the microneedle device has been put.