| 摘要 |
<p>The invention provides a method of synthesizing sevoflurane. The method comprises the following steps that: taking hexafluoro isopropanol as the raw material and reacting it with trioxymethylene (or paraformaldehyde) in the presence of acids to generate di-hexafluoro isopropanol formal derivatives, adding anhydrous aluminum trihalide to generate halomethyl 2, 2,2-trifluoro-1-(trifluoromethyl) ethyl ether, then reacting the halomethyl compound with metal fluoride to form the sevoflurane. The method has low cost, and the reaction condition is easy to implement, and produces sevoflurane in large scale.</p> |
