发明名称 NON-PEPTIDE MACROCYCLIC HISTONE DEACETYLASE (HDAC) INHIBITORS AND METHODS OF MAKING AND USING THEREOF
摘要 Compounds of Formula (I) or (II), and methods of making and using thereof, are described herein. wherein M represents a macrolide subunit, n is a C1-6 group, optionally containing one or more heteroatoms, wherein the carbon atoms and/or heteroatoms are in a linear and/or cyclic arrangement, D is an alkyl or aryl group, A is a linking group connected to D, B is an alkyl, wherein M represents a macrolide subunit, R1, R2 and R4 are independently are selected from hydrogen, a C 1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-6 alkanoate group, a C2-6 carbamate group, a C2-6 carbonate group, a C2-6 carbamate group, or a C2-6 thiocarbamate group, R3 is hydrogen or -OR5, R5 is selected from a group consisting of Hydrogen, a C1-6 alkyl hgroup, a C2-6 alkenyl group, a C2-6 alkynyl group, C1-6 alkanoate group, C2-6 carbamate group, C2-6 carbonate group, C2-6 carbamate group, or C2-6 thiocarbamate group.
申请公布号 WO2009006403(A3) 申请公布日期 2010.01.07
申请号 WO2008US68787 申请日期 2008.06.30
申请人 GEORGIA TECH RESEARCH CORPORATION;OYELERE, ADEGBOYEGA 发明人 OYELERE, ADEGBOYEGA
分类号 A01N43/02;A61K31/335;A61K31/35 主分类号 A01N43/02
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