ASTHMA SUSCEPTIBILITY LOCI LOCATED AT CHROMOSOME 1q31 FOR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS

摘要

Methods and composition are provided for diagnosing pediatpc onset asthma based on the single nucleotide polymorphism on chromosome 1q31 wherein said single nucleotide polymorphism is set forth in Table 2 or Table 6 of the instant invention Method and composition are also provided for treating and preventing asthma or other inflammatory conditions in a patient in need thereof comppsing administering an effective amount of an at least one inhibitor which reduces the expression of DENND1 B gene product.