发明名称 |
Method for reducing the fucose content of recombinant proteins |
摘要 |
<p>The present invention relates to a method for reducing the fucose content of a recombinant protein, which comprises expressing in an animal cell the recombinant protein and FUCA1, an FUCA1 mutant, FUCA2, or a fragment of FUT8 localization domain; or with a fusion protein of a fragment of FUT8 localization domain and a fragment of FUCA1, a FUCA1 mutant or FUCA2. Therefore, the antibody expressed according to the method of the present invention exhibits a reduced fucose content in their Fc regions, which leads to the improvement in the therapeutic effect thereof.</p> |
申请公布号 |
EP2141237(A1) |
申请公布日期 |
2010.01.06 |
申请号 |
EP20090000153 |
申请日期 |
2009.01.08 |
申请人 |
MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE |
发明人 |
KIM, JUNG-SEOB;MOON, JAE-HOON;OH, MEE SOOK;LEE, KONG JU;YOON, YEUP |
分类号 |
C12N15/62;C07K16/18;C12N9/10;C12N9/24 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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