| 摘要 |
<p>The present invention relates to a a method for diagnosing chronic obstructive pulmonary disease (COPD) in a human subject or the risk of a human subject to develop COPD comprising the steps of:
- providing a sample from a human subject,
- determining the amount of interleukin-1 receptor 4 (ST2), caspase-cleaved cytokeratin-18 (ccCK-18), histones, heat shock protein 27 (HSP27), heat shock protein 70 (HSP70) and/or heat shock protein 90 alpha (HSP90 alpha) in said sample,
- diagnosing COPD when the amount of ST2, ccCK-18, histones, HSP27, HSP70 and/or HSP90 alpha is increased compared to the amount of ST2, ccCK-18, histones, HSP27, HSP70 and/or HSP90 alpha in healthy human subjects, or
- diagnosing the risk to develop COPD when the amount of ST2, ccCK-18, histones and/or HSP70 is reduced compared to the amount of ST2, ccCK-18, histones and/or HSP70 in healthy human subjects.</p> |
