摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a new factor involving regulation of chromatin function. <P>SOLUTION: The present invention provides an enzyme (NHK-1) phosphorylating histone in nucleosome and found from Drosophila and a gene encoding the enzyme (NHK-1). The NHK-1 is a new factor phosphorylating 119th threonine of C terminal of histone H2A dependently on a chromatin structure. The phosphorylated site is preserved in species. It has been clarified that the site plays an important role in proliferation of cell proliferation and the site is highly phosphorylated in human cancer tissues. <P>COPYRIGHT: (C)2005,JPO&NCIPI</p> |