| 摘要 |
PURPOSE: An antioxidant-chitosan complex is provided to enhance stability of the antioxidant in aqueous media and minimize denaturation of the antioxidant by temperature, light ray, oxygen, and water. CONSTITUTION: An antioxidant-chitosan complex is produced by reacting chitosan with α-lipoic acid or glutathione antioxidant and chitosan under the presence of 3-dimethyl-aminopropyl-N-ethylcarbodimide. The reaction is performed under the presence of N-hydroxysucciinimide and acid as catalyst. A method for producing the antioxidant-chitosan complex comprises: a step of reacting the antioxidant and succinic acid under the presence of 3-dimethyl-aminopropyl-N-ethyl carbodimide; and a step of reacting the 3-antioxidant-carbonyl propanoic acid and chitosan under the presence of 3-dimethyl-aminopropyl-N-ethyl carbodimide. The antioxidant is coenzyme Q10, α-tocopherol, retinol, ascorbic acid, or butylated hydroxy toluene.
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