发明名称 |
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS, TREATMENT, AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED NEUROLOGICAL DISEASES |
摘要 |
<p>One aspect of the invention relates to a method of treating or preventing a neurodegenerative disease, comprising the step of administering to a patient in need thereof a therapeutically effective amount of an inhibitor of the formation of advanced glycation end products. Another aspect of the invention relates to a proteasome activity-based screening assay to select compounds which may be useful for treating or preventing a neurodegenerative disease, and the materials used therein. Yet another aspect of the invention relates to molecules, and methods of use thereof, which bind at or adjacent to SOD-I Trp32, including molecules that bind in a site adjacent to SOD-I Trp32 whether or not it is oxidized, for treating or preventing neurodegenerative disease.</p> |
申请公布号 |
EP2139460(A1) |
申请公布日期 |
2010.01.06 |
申请号 |
EP20080744133 |
申请日期 |
2008.03.20 |
申请人 |
BRANDEIS UNIVERSITY |
发明人 |
AGAR, JEFFREY, N.;PETSKO, GREGORY, A.;RINGE, DAGMAR;NOVAK, WALTER, R.P. |
分类号 |
A61K31/16;A61K31/35;A61K31/4015;A61K31/404;A61K31/415;A61K31/4155;A61K31/416;A61K31/4402;A61K31/4439;A61K31/517;A61K31/55;A61K31/63;A61K31/635 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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