摘要 |
The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastroin--testinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form i s designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention als o encompasses methods of trating patients by administering this coordinated release, gastroprotective, antiarthitic/analgesic combinati on unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages. |