发明名称 |
Mouse with deficiency of glutamate transporter GLAST function |
摘要 |
The present invention provides a GLAST knockout mouse lacking the function of an endogenous glutamate transporter GLAST gene, which shows: 1) an intraocular pressure within the normal range; and 2) a reduction in the number of cells in the retinal ganglions when compared with a wild-type normal mouse. Owing to the ocular properties, this knockout mouse is useful as a model for normal tension glaucoma. By using this knockout mouse, a compound useful for the treatment of normal tension glaucoma can be screened.
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申请公布号 |
US7642399(B2) |
申请公布日期 |
2010.01.05 |
申请号 |
US20040553051 |
申请日期 |
2004.04.13 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
TANAKA KOHICHI;HARADA TAKAYUKI |
分类号 |
A01K67/027;C12N5/00;C12N15/00;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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