发明名称 |
Zinc-containing sustained-release composition, its preparation, and method for producing the same |
摘要 |
With a simple and high-yield production method, a zinc-containing sustained-release composition capable of stabilizing a physiologically active protein or peptide, typically G-CSF by precipitation and retaining drug efficacy for several days in a living body owing to its sustained releasability is provided. Concretely, a zinc-containing sustained-release composition produced by forming a precipitate by mixing a physiologically active protein or peptide, a water-soluble zinc salt, a water-soluble carbonate and/or a water soluble phosphate aqueous solution. The zinc-containing sustained-release composition may be administered as a zinc-containing sustained preparation by adding a pharmaceutically acceptable additive as is necessary. |
申请公布号 |
US7642230(B2) |
申请公布日期 |
2010.01.05 |
申请号 |
US20050555191 |
申请日期 |
2005.11.01 |
申请人 |
LTT BIO-PHARMA CO., LTD. |
发明人 |
KIMURA MICHIO;ETO TOMOKO;MIZUSHIMA YUTAKA |
分类号 |
A61K38/02;A61K9/00;A61K9/14;A61K9/19;A61K33/30;A61K33/42;A61K38/18;A61K38/19;A61K38/20;A61K38/21;A61K38/27;A61K47/26;A61K47/36;C07K16/24 |
主分类号 |
A61K38/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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