发明名称 |
Inhibitors of acyl glucosaminyl inositol amidase and methods of use |
摘要 |
The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring compounds obtained from marine sponges and other organisms. The invention further provides methods for using the compounds to inhibit virulence and reduce antibiotic resistance of mycothiol-producing bacteria.
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申请公布号 |
US7642280(B2) |
申请公布日期 |
2010.01.05 |
申请号 |
US20040474138 |
申请日期 |
2004.03.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;NATIONAL INSTITUTES OF HEALTH |
发明人 |
FAHEY ROBERT C.;NEWTON GERALD L.;BEWLEY CAROLE A.;NICHOLAS GILLIAN |
分类号 |
A61K31/415;A61K31/15;A61P31/04;C07C225/06;C07C259/00;C07C279/12;C07D213/16;C07D213/36;C07D223/00;C07D233/88;C07D413/12;C07D413/14;C07H15/12 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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