发明名称 |
7-CARBOXYMETHYLOXY-3 , 4 , 5-TRIMETHOXY FLAVONE MONOHYD RATE, THE PREPARATION METHOD AND USES THEREOF |
摘要 |
<p>The present invention relates to a process to prepare 7-carboxymethyloxy-3',4',5-trimethoxy flavone using 3',5,7-trihydroxy-4'-methoxy flavone-7-rutinoside as starting material. The process comprises the steps 1) selective 3-hydroxy methylation followed by acidic hydrolysis of the glycoside bond, 2) 7-hydroxy alkylation with alpha-haloacetate, 3) 5-hydroxy methylation and 4) deprotection of the 7-esther group.</p> |
申请公布号 |
PT1660074(E) |
申请公布日期 |
2009.12.31 |
申请号 |
PT20040774508T |
申请日期 |
2004.09.04 |
申请人 |
DONG-A PHARMACEUTICAL CO., LTD. |
发明人 |
MOOHI YOO;DONG SUNG KIM;YONG DUCK KIM;WONBAE KIM |
分类号 |
A61K31/352;A61P1/00;A61P1/04;C07D311/30 |
主分类号 |
A61K31/352 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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