发明名称 |
NEW PEPTIDE OF THE HER-2/neu ONCOPROTEIN (HER-2 (85-94)) FOR CANCER VACCINATION |
摘要 |
The HER-2(85-94) peptide determines the region of 10 amino acids (L I A H N Q V R Q V) from the extracellular region of the HER-2/neu oncoprotein. Said peptide is bound with increased degree of affinity to HLA-A2.1 histocompatibility molecules and sufficiently antigenic since it stimulates the production of interferon- from cytotoxic CD8 T lymphocytes acting against cancer cells expressing HLA-A2.1 molecules and HER-2/neu.The HER-2(85-94) peptide is differentiated from the so-far antigenic peptides of the HER-2/neu oncoprotein because it is the single one which is recognized by increased frequencies of CD8 T lymphocytes in the peripheral blood of patients suffering from breast cancer. Furthermore, said peptide is so far the only one that has been used as a protecting and therapeutic vaccine HLA-A2.1 and has treated diagenous rats from allied ALC cancer cells co-expressing HLA-A2.1 and HER-2/neu. This peptide is destined for fist-phase clinical assays on patients suffering from prostate and breast cancer. |
申请公布号 |
GR20080100369(A) |
申请公布日期 |
2009.12.31 |
申请号 |
GR20080100369 |
申请日期 |
2008.05.29 |
申请人 |
BAXEVANIS (KATA POSOSTO 40%) KONSTANTINOS;PAPAMICHAIL (KATA POSOTO 20%) MICHAIL;GKRITZAPIS (KATA POSOSTO 20%) ANGELOS;PEREZ (KATA POSOSTO 20%) SONIA |
发明人 |
BAXEVANIS KONSTANTINOS;PAPAMICHAIL MICHAIL;GKRITZAPIS ANGELOS;PEREZ SONIA |
分类号 |
C07K14/705;A61K38/00;C07K7/06;C07K14/82 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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