MERCAPTOIMIDAZOLES AS CCR2 RECEPTOR ANTAGONISTS

摘要

THE PRESENT INVENTION RELATES TO A COMPOUND OF FORMULA (1) A N-OXIDE, A PHARMACEUTICALLY ACCEPTABLE ADDITION SALT, A QUATERNARY AMINE, A POLYMORPHIC FORM OR A STEREOCHEMICALLY ISOMERIC FORM THEREOF, WHEREIN R1 REPRESENTS HYDROGEN, C1-6ALKYL, C3-7CYCLOALKYL, C1-6ALKYLOXYC1-6ALKYL, DI(C1-6ALKYL)AMINOC1-6ALKYL, ARYL OR HETEROARYL; EACH R2 INDEPENDENTLY REPRESENTS HALO, C1-6ALKYL, C1-6ALKYLOXY, C1-6ALKYLTHIO, POLYHALOC1-6ALKYL, POLYHALOC1-6ALKYLOXY, CYANO, AMINOCARBONYL, AMINO, MONO-OR DI(C1-4ALKYL)AMINO, NITRO, ARYL OR ARYLOXY; R3 REPRESENTS HYDROGEN, CYANO, OPTIONALLY SUBSTITUTED C1-6ALKYL, C(=O)-O-R5, C(=O)-NR6AR6B, C(=S)-NR6AR6B, S(=O)2-NR6AR6B OR C(=O)-R7; R4 REPRESENTS HYDROGEN OR C1-6ALKYL; N IS 1,2,3,4 OR 5; Z REPRESENTS A CYCLIC RING SYSTEM. THE INVENTION ALSO RELATES TO PROCESSES FOR PREPARING THE COMPOUNDS OF FORMULA (I), THEIR USE AS CCR2 ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM.