| 发明名称 |
FACTOR VIII MUTEINS WITH REDUCED IMMUNOGENICITY |
| 摘要 |
The invention relates to modified Factor VIII molecules with reduced N-linked glycosylation and reduced immunogenicity. The invention also relates to methods of using modified Factor VIII molecules, for example, to treat patients afflicted with hemophilia.
|
| 申请公布号 |
CA2728708(A1) |
申请公布日期 |
2009.12.30 |
| 申请号 |
CA20092728708 |
申请日期 |
2009.06.25 |
| 申请人 |
BAYER HEALTHCARE LLC |
发明人 |
ASWAD, FRED JULLIEN;HARKINS, RICHARD;LIU, HSIAO-LAI;MURPHY, JOHN E.;WU, FAYE;ZHU, YING |
| 分类号 |
C07K14/755;A61K38/37;A61P7/04;C12N15/12 |
主分类号 |
C07K14/755 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
