发明名称 |
Gene expression profiles to predict breast cancer outcomes |
摘要 |
Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer. Methods of the invention further include means for evaluating gene expression profiles, including microarrays and quantitative polymerase chain reaction assays, as well as kits comprising reagents for practicing the methods of the invention. |
申请公布号 |
AU2009262894(A1) |
申请公布日期 |
2009.12.30 |
申请号 |
AU20090262894 |
申请日期 |
2009.06.01 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION;WASHINGTON UNIVERSITY;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;BRITISH COLUMBIA CANCER AGENCY BRANCH |
发明人 |
CHARLES M. PEROU;JAMES STEPHEN MARRON;JOEL S. PARKER;MATTHEW ELLIS;TORSTEN O. NIELSEN;MAGGIE CHEANG;ANDREW NOBEL;PHILIP S. BERNARD;ELAINE MARDIS |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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