发明名称 |
Formulations of hydrophobic proteins in an immunogenic composition having improved tolerability |
摘要 |
The present invention provides a method for producing a less-painful immunogenic composition of a hydrophobic protein in a pharmaceutically acceptable carrier suitable for administering to a mammal, comprising the steps of (a) solubilizing said hydrophobic protein with a zwitterionic detergent to make a first composition; (b) altering said first composition, such that the altered composition produces a reduction in pain as measured in the rat footpad model as compared to said first composition. |
申请公布号 |
ZA200605393(B) |
申请公布日期 |
2009.12.30 |
申请号 |
ZA20060005393 |
申请日期 |
2006.06.29 |
申请人 |
WYETH |
发明人 |
HOISETH SUSAN KAY;METCALF, III, THOMAS, NEWELL;MATSUKA, YURY VLADIMIROVICH;HAGEN, MICHAEL |
分类号 |
A61K;A61K39/095;A61K47/18;A61P |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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