发明名称 |
IMMUNOMODULATORY AGENTS AND METHODS OF USE |
摘要 |
An antisense oligonucleotide compound, composition, vaccine and methods for treating a variety of conditions characterized by up-regulation of IL-10 in a mammalian subject are disclosed. The compound (i) is composed of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5' exocyclic carbon of an adjacent subunit, (ii) is capable of uptake by monocytes, lymphocytes, and dendritic cells in a mammalian subject, (iii) contains between 10-40 nucleotide bases, and (iv) has a base sequence effective to hybridize to at least 12 contiguous bases of a target sequence contained in an exon-2 or exon-4 slice site region of human IL-10 pre-mRNA. |
申请公布号 |
WO2009086469(A3) |
申请公布日期 |
2009.12.30 |
申请号 |
WO2008US88339 |
申请日期 |
2008.12.24 |
申请人 |
AVI BIOPHARMA, INC.;MOURICH, DAN, V.;IVERSEN, PATRICK, L. |
发明人 |
MOURICH, DAN, V.;IVERSEN, PATRICK, L. |
分类号 |
C07H21/04 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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