摘要 |
High-throughput mammalian and medium-throughput oocyte-based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers are disclosed Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans The electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3 The assays provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function and thereby modulate salty taste In addition, these compounds may be used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels |
申请人 |
SENOMYX, INC.;MOYER, BRYAN;ZLOTNIK, ALBERT;HEVEZI, PETER;SOTO, HORTENSIA;LU, MIN;GAO, NA;SERVANT, GUY;BRUST, PAUL;WILLIAMS, MARK;KALABAT, DALIA;WHITE, EVAN, CARL;SAGANICH, MICHAEL;LAITA, BIANCA;DAHAN, DAVID |
发明人 |
MOYER, BRYAN;ZLOTNIK, ALBERT;HEVEZI, PETER;SOTO, HORTENSIA;LU, MIN;GAO, NA;SERVANT, GUY;BRUST, PAUL;WILLIAMS, MARK;KALABAT, DALIA;WHITE, EVAN, CARL;SAGANICH, MICHAEL;LAITA, BIANCA;DAHAN, DAVID |