COMPOUNDS, COMPOSITIONS, AND METHODS USEFUL FOR MODULATING THE EXPRESSION OF HISTONE DEACETYLASE (HDAC) GENE EXPRESSION AND/OR ACTIVITY

摘要

The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of histone deacetylase, particularly histone deacetylase 4 expression and/or activity. The present invention is also directed to compounds, compositions, and methods relating to traits, diseases and conditions that respond to the modulation of expression and/or activity of HDAC4 genes or other cellular processes that mediate the maintenance or development of such traits, diseases and conditions. Exemplarity diseases or traits associated with HDAC4 expression or activity include cellular proliferative disorders such as oncogenic disorders exemplified by cancer and cardiovascular diseases. Specifically, the invention relates to double stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against HDAC4 gene expression, including cocktails of such small nucleic acid molecules and lipid nanoparticle (LNP) formulations of such small nucleic acid molecules. The present invention also relates to small nucleic acid molecules, such as siNA, siRNA, and others that can inhibit the function of endogenous RNA molecules, such as endogenous micro-RNA (miRNA) (e.g, miRNA inhibitors) or endogenou