摘要 |
The invention relates to a solid pharmaceutical composition comprising a solid dispersion containing at least one active principle and a pharmaceutically-acceptable polymer matrix which comprises a mixture of (i) polydextrose, in the form of a continuous polydextrose phase and (ii) at least one polymer other than polydextrose, in the form of a continuous phase, whereby the polydextrose is in a concentration of at least 20 wt.- % and the at least one polymer other than polydextrose is in a concentration of at least 20 wt.- % in relation to the total weight of the pharmaceutically-acceptable polymer matrix, wherein at least one polymer other than polydextrose selected from the group consisting of cellulose-based polymers, vinyl homo- and copolymers, acrylic and methacrylic polymers, chemically modified starches, pectins, chitin derivatives, gum tragacanth, gelatin, sodium alginate, pullulan, gum arabic, guar gum, agar-agar, xanthan gum, polyalkylene oxides, and blends thereof. There also described a solid composition, a pharmaceutical tablet, a pharmaceutical gelatin tablet and a molded pharmaceutical tablet comprising said solid pharmaceutical composition. |