METHOD OF PREPARING BIODEGRADABLE COVERED POROUS POLYMER MICROSPHERES FOR SUSTAINED-RELEASE DRUG DELIVERY AND TISSUE REGENERATION

摘要

PURPOSE: A method for preparing biodegradable covered porous polymer microspheres is provided to control a pore size of microspheres, and to prepare porous polymer microspheres capable of ensuring sustained release control and persistence of a sealed drug. CONSTITUTION: A method for preparing biodegradable covered porous polymer microspheres comprises the steps of: dissolving or suspending a bio-active material in a polymer solution that a biodegradable polymer is dissolved in an organic solvent to prepare a polymer solution containing a bio-active material; adding a hydrogen peroxide-containing compound to the polymer solution and mixing the mixture to prepare water-in-oil type emulsion; emulsifying the water-in-oil type emulsion in a emulsion stabilizer solution to prepare oil-in-water type emulsion; and adding a hydrogen peroxide decomposition catalyst to the oil-in-water type emulsion to degrade hydrogen peroxide and evaporate organic solvent.