CRYSTALLINE FORM OF 5(S)-(2'-HYDROXYETHOXY)-20(S)-CAMPTOTHECIN
摘要
<p>A 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.</p>
申请公布号
EP2019591(A4)
申请公布日期
2009.12.30
申请号
EP20070784102
申请日期
2007.05.24
申请人
DR. REDDY'S LABORATORIES LIMITED;DR. REDDY'S LABORATORIES, INC.