AN IMPROVED PROCESS FOR PRODUCTION OF BICALUTAMIDE USEFUL IN THE TREATMENT OF PROSTATE CANCER

摘要

The invention relates to an improved process for production of Bicalutamide useful in the treatment of prostate cancer by oxidizing N[4-Cyano-3-trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methyl propanamide with Hydrogenperoxide in the presence of ethylacetate as solvent, methanesulfonic acid and sodiumtungstate as catalysts, washing the reaction mixture with sodiumthiosulphate solution or sodium metabisulphite solution, charcolising and evaporating the reaction mixture adding hydrocarbon solvent, cooling to room temperature and filtering.