(Leu3 leu4)-arginine and lysine-vasopressins - natriuretics with low hypertensive activity useful for treatment of oedema

摘要

The novel polypeptides are of formula (I): (where Q is Arg or Lys, and Y is Cys, beta-mercaptopropionyl or Gly-Cys), all the amino-acids being in the 1-configuration, together with their non-toxic, therapeutically useful acid addn. salts. They may be prepd. by several methods, e.g. oxidn. and removal of the protectings gps. of a peptide of formula (II): (where R5 and r6 are H or sulphydryl protecting gps., and R7 is H, NH2 or Gly-NH). Many peptide inters. in the prepn. of (I) are also novel.