COMPOSITION FOR TRANSDERMAL ADMINISTRATION COMPRISING LOXOPROFEN OR ITS SALT, AND TRANSDERMAL PLASTER CONTAINING SAME

摘要

PURPOSE: A transdermal absorption composition containing loxoprofen or its salt is provided to suppress generation of crystallization and ensure adhesion which is applicable to joint of human body. CONSTITUTION: A transdermal absorption composition contains 0.5-50 weight% of loxoprofen or its salt, 7-15 weight% of glycerol monolaurate as absorber, 20-92 weight% of adhesion polymer and 0.1-20 weight% of sorbitan ester as a stabilizing agent. The sorbitan ester is sorbitan sesquioleate or sorbitan sesquistearate. The composition further contains acetic acid, lactic acid or myristic acid. The salt of loxoprofen is loxoprofen sodium.