发明名称 |
MICROMECHANICAL DEVICES FOR CONTROL OF CELL-CELL INTERACTION, AND METHODS OF USE THEREOF |
摘要 |
The development and function of living tissues depends largely on interactions between cells that can vary in both time and space; however, temporal control of cell-cell interaction is experimentally challenging. By employing a micromachined silicon substrate with moving parts, herein is disclosed the dynamic regulation of cell-cell interactions via direct manipulation of adherent cells with micron-scale precision. The inventive devices and methods allow mechanical control of both tissue composition and spatial organization. The inventive device and methods enable the investigation of dynamic cell-cell interaction in a multitude of applications, such as intercellular communication, spanning embryogenesis, homeostasis, and pathogenic processes. |
申请公布号 |
EP2137299(A2) |
申请公布日期 |
2009.12.30 |
申请号 |
EP20080782741 |
申请日期 |
2008.03.10 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BHATIA, SANGEETA, N.;HUI, ELLIOT |
分类号 |
C12M3/00;C12N5/00 |
主分类号 |
C12M3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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