A single-use medical equipment package cover comprising a solid preformed shell to cover the functional part of a medical instrument or surgical device and a trailing soft plastic cover or plastic sheath for the rest of the surface of the medical instrument or surgical device. The medical equipment package cover is applied in a folded or stowed configuration and is then unfolded to a deployed configuration. The trailing plastic cover may be transparent and removably affixable to a lens surface or a monitor surface. Unfolding of the removably affixed sheath imparts an interpersonal barrier to block aerial or sputum transfer between patient and medical personnel operating medical equipment being deployed on and within the patient.