发明名称 |
INHIBITORS OF ONCOGENIC ISOFORMS AND USES THEREOF |
摘要 |
Isoform-binding molecules that specifically bind to one or more isoforms expressed and/or associated with oncogenic phenotypes in a hyperproliferative cell (e.g., a cancerous or tumor cell) are disclosed. The isoform-binding molecules can be used to treat, prevent and/or diagnose cancerous conditions and/or disorders. Methods of using the isoform-binding molecules to selectively detect oncogenic isoforms, to reduce the activity and/or induce the killing of a hyperproliferative cell expressing an oncogenic isoform in vitro, ex vivo or in vivo are also disclosed. Diagnostic and/or screening methods and kits for evaluating the function or expression of an oncogenic isoform are also disclosed. |
申请公布号 |
WO2009100105(A3) |
申请公布日期 |
2009.12.30 |
申请号 |
WO2009US33031 |
申请日期 |
2009.02.04 |
申请人 |
ATTOGEN INC.;CHANG, XIAO-JIA;SCHWERTSCHLAG, ULLRICH, S. |
发明人 |
CHANG, XIAO-JIA;SCHWERTSCHLAG, ULLRICH, S. |
分类号 |
C07K16/18;C07K16/46 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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