TREATMENTS OF DISEASE OR DISORDERS USING NANOPARTICLES FOR FOCUSED HYPERTHERMIA TO INCREASE THERAPY EFFICACY

摘要

The present invention generally relates to methods for the treatment of a variety of diseases and disorders utilizing systemically- introduced nanoparticles to create focused hyperthermia of a target area so as to enhance the efficacy of additional therapies. Generally, the present invention describes a method for treating tumors or target tissues using localized hyperthermia to enhance the effect of other therapies such as drug treatments and radiation treatments. Advantages of the methods herein include an increase of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia, in the treatment area. Further, in certain embodiments, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as anti-hypoxic agents.