发明名称 |
MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 |
摘要 |
Disclosed are macrocyclic compounds of formulae I-V, which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90. |
申请公布号 |
EP2136799(A1) |
申请公布日期 |
2009.12.30 |
申请号 |
EP20070811232 |
申请日期 |
2007.08.10 |
申请人 |
UNIVERSITE DE STRASBOURG;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
WINSSINGER, NICOLAS;BARLUENGA, SOFIA;KARPLUS, MARTIN |
分类号 |
A61K31/365;C07D313/00;C07D493/00 |
主分类号 |
A61K31/365 |
代理机构 |
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地址 |
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