| 摘要 |
Wire guides and methods of using an elongate wire guide with a first end portion and a flexible second end portion having an increased surface area is provided. The second end portion comprises a nominal outer circumference disposed about a longitudinal axis and having a first outer surface including the nominal outer circumference and defining a first surface area. Protuberances, indentations, peaks, and/or valleys are disposed substantially circumferentially about the nominal outer circumference and defining an effective perimeter greater than the nominal outer circumference and having a second outer surface defining a second surface area greater than the first surface area. Hydrophilic materials and therapeutic agents may be disposed partially on the second end portion and a coating, and a membrane may be disposed about second end portion and coating to form reservoirs or lumens for delivering hydrophilic materials and delivering therapeutic agents.
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