发明名称 |
In vitro sorting method |
摘要 |
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.
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申请公布号 |
US7638276(B2) |
申请公布日期 |
2009.12.29 |
申请号 |
US20040861930 |
申请日期 |
2004.06.04 |
申请人 |
454 LIFE SCIENCES CORPORATION |
发明人 |
GRIFFITHS ANDREW;TAWFIK DAN |
分类号 |
C12N15/09;C12Q1/68;C12N9/02;C12N15/10;C12P17/18;C12Q1/32;C12Q1/66;G01N33/15;G01N33/50;G01N33/567 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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