USE OF CARBON-2-MODIFIED-19-NOR-VITAMIN D ANALOGS TO INDUCE THE FORMATION OF NEW BONE

摘要

It has been discovered that the 2-carbon-modified derivatives of 1.alpha.,25 - dihydroxyvitamin D3 specifically stimulate osteoblasts to form new bone. The ability of the 2-carbon-modified vitamin D analogs to stimulate new bone formation suggest that these compounds can be used where synthesis of new bo ne is required. Thus, these compounds can be used either systemically or locall y to stimulate the growth of bone transplants, to increase the rate of fractur e healing and thereby reduce the time required for the healing of fractures, t he stimulation of bone growth when required for replacement surgery, and also f or the growth of bone to implants or other devices required to maintain the skeleton or teeth in the proper positions.