PROCESS FOR PREPARING N-[5-(DIPHENYLPHOSPHINOYLMETHYL)-4-(4-FLUOROPHENYL)-6-ISOPROPYLPYRIMIDIN-2-YL]-N-METHYLMETHANESULPHONAMIDE

摘要

N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2 - yl]-N-methylmethanesulphonamide of the formula (see formula I) is prepared by reaction of [4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methylsulphonylamino)pyrimidin-5-yl]methanol with chlorodiphenylphosphine. Compound I is an intermediate in the synthesis of pharmaceutically active compounds, in particular HMG-Co A. reductase inhibitors.